Fat Loss — Advanced Metabolic
Tirzepatide + HCG — dual-agonist with testicular maintenance.
Overview
Dual GIP/GLP-1 agonist (Tirzepatide) for aggressive metabolic response, paired with low-dose HCG to maintain Leydig-cell function through the extended caloric deficit. Testosterone decline during prolonged weight loss is well-documented — HCG prevents the fatigue/libido crash that often accompanies aggressive protocols. This is a more potent stack than Sema-only; reserved for researchers who've tried GLP-1 and want stronger response.
Who it's for
- 01Researchers with prior GLP-1 experience
- 02Significant weight to lose (30+ lb target)
- 03Researchers noticing testosterone/energy crash during long cuts
What's inside — 2 compounds
$49.00
View PDP →- Dose
- 2.5 mg
- Frequency
- Weekly
- Weeks
- 1-14
- Category
- peptides
Titration: 2.5 wk 1-4, 5 wk 5-8, 7.5 wk 9-11, 10 wk 12-14
$47.00
View PDP →- Dose
- 500 IU
- Frequency
- 2× weekly
- Weeks
- 1-14
- Category
- peptides
Low dose — NOT PCT dose. Maintains volume + partial endogenous T through deficit
Weekly Protocol
Tirzepatide titration is even more critical than Semaglutide — side effects are more intense. HCG runs throughout at low dose. Post-protocol, a short Nolvadex PCT (2 weeks, 20 mg) addresses any mild HPTA suppression from sustained HCG.
| Compound | Dose | Frequency | Weeks |
|---|---|---|---|
| Tirzepatide 5mg | 2.5 mg | Weekly | 1-14 |
| HCG 5000IU | 500 IU | 2× weekly | 1-14 |
Expected Outcomes
- 20–40 lb weight loss over 14 weeks
- Preserved testosterone / energy / libido (HCG effect)
- Faster and deeper appetite suppression than Sema-alone
- No full HPTA suppression, but HCG is mildly suppressive — short break after
Support Requirements
Items referenced in the protocol. Some are included in the stack; support-only items may need to be ordered separately.
Optional short PCT post-protocol
Safety & Warnings
- Tirzepatide side effects (nausea, GI upset) are more pronounced than Semaglutide — titrate slowly.
- HCG at 500 IU 2×/week is mildly suppressive over 14 weeks — bloodwork post-protocol.
- Pancreatitis risk with GLP-1s — abdominal pain = stop immediately.
- Not a first weight-management protocol. Run Sema first.
Frequently Asked
Why add HCG for a weight-loss stack?
Published data shows testosterone drops 15-30% during sustained weight loss. HCG at 500 IU 2×/week prevents the crash without the logistical complexity of TRT.
Can I swap Tirzepatide for Retatrutide?
Yes — Retatrutide is the emerging triple-agonist (GLP-1/GIP/Glucagon). More potent, less long-term data. Beginner dose 2 mg/week.
Research disclaimer
All stack suggestions reflect the published literature and are provided for research-reference purposes only. Individual protocols require compound-specific planning. Consult the stacking theory guide before designing your protocol. Not medical advice.