S-23: The Strongest SARM — Why It Requires Serious PCT
S-23 is the most potent SARM available — a full androgen receptor agonist originally developed as a male contraceptive. Learn about S-23 cycles, dosing (10-25mg/day), severe suppression, and why PCT is non-negotiable.
Novo Pharma Research Team
Novo Pharma Research · peer-reviewed literature synthesis
S-23: The Strongest SARM — Why It Requires Serious PCT
References:
- Jones A, et al. Nonsteroidal selective androgen receptor modulators as male hormonal contraceptives. J Clin Endocrinol Metab. 2009;94(10):4442-4448. PMID: 19789204
- Chen J, et al. A selective androgen receptor modulator for hormonal male contraception. J Pharmacol Exp Ther. 2005;312(2):546-553. PMID: 15356213
- Narayanan R, et al. Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal. 2008;6:e010. PMID: 18612376
- Mohler ML, et al. Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. J Med Chem. 2009;52(12):3597-3617. PMID: 19432422
- Kearbey JD, et al. Selective androgen receptor modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007;24(2):328-335. PMID: 17063395
- GTx Inc. Preclinical pharmacokinetic data, S-23. Investigator's Brochure.
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